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Codexis

Merck extends biocatalysis collaboration with Codexis

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Biocatalyst specialist Codexis has signed a three-year extension of its catalyst and process development collaboration with Merck to develop enzymes for use in pharmaceutical manufacturing. 

The collaboration between Codexis and Merck has already been ongoing for a number of years, with the two companies developing improved production processes for some of Merck's most important new products, such as Januvia (sitagliptin) for diabetes, asthma drug Singulair (montelukast) and  recently launched hepatitis C therapy Victrelis (boceprevir). 

Pharma manufacturing news in brief

Excipients trade body IPEC will set up a branch in India next month, plus updates for Codexis, SGS International, Vetter and Novozymes Biopharma.

FDA approves greener process for Januvia production

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The US Food and Drug Administration (FDA) has approved a new, more environmentally-friendly manufacturing process for Merck & Co's diabetes drug Januvia developed in collaboration with Codexis. 

Biocatalysis specialist Codexis said the approved process, which won the Presidential Green Chemistry Award in 2010, can improve the overall yield of sitagliptin, while significantly decreasing waste by-products. 

Codexis and Merck develop green Victrelis production

Merck has teamed up with catalyst specialist Codexis to develop a more efficient manufacturing process for recently-approved hepatitis C treatment Victrelis.

Merck was granted approval for NS3/4A protease inhibitor Victrelis (boceprevir) in the

Biocatalyst firm Codexis posts sales increase

Codexis has reported a healthy increase in revenues in the second quarter of 2010 which suggests that pharmaceutical companies are continuing to invest in cleaner, greener manufacturing approaches.

Codexis, which specialises in biocatalyst technologies for chemical synthesis, reported revenues of $24.5 million in the quarter, up 28% from a year ago and putting it on track to post an operating profit for the first time this year.

Manufacturing news in brief

Pharmafocus' round-up of developments in pharmaceutical manufacturing includes facility updates from Dishman, Alexion, Stirling Products, RL Fine Chemicals and Cambrex, as well as a Dow spin-out and catalyst deal for Codexis.

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