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Healthy cells in lungs can repair the damage from smoking

Human lungs have the ‘magical’ ability to repair the cancerous mutations caused by smoking cigarettes, but only if people quit smoking.

The findings were published in Nature and showed that the few cells that escape damage in a smoker can repair the lungs. The effect has been seen in patients that smoked a pack a day for 40 years before giving up. Previously the mutations that lead to lung cancer from smoking were considered to be permanent damage.

Boehringer's Ofev scores first-of-its-kind FDA approval in rare lung disease

Boehringer Ingelheim’s Ofev (nintedanib) capsules have now secured marketing authorisation in the US, it has emerged, for the treatment of interstitial lung disease associated with systemic sclerosis or scleroderma (SSc-ILD), a rare lung condition.

The decision, made under the FDA’s Priority Review pathway, was supported by data which demonstrated that the drug reduced lung function decline compared to placebo, and makes Ofev the first and only FDA-approved therapy to slow the rate of decline in this condition,

Boehringer and Roche IPF drugs win FDA approval

Boehringer image

The FDA has approved both Roche’s Esbriet (pirfenidone) and Boehringer Ingelheim’s Ofev (nintedanib) for the treatment of the fatal lung disease Idiopathic Pulmonary Fibrosis (IPF).

These new drugs are the first treatments for IPF available in the US. Esbriet previously became the first marketed drug for IPF globally when it was approved in Europe in 2011, and has since been shown the green light in Norway, Iceland and Canada.

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