ovarian cancer

Johnson & Johnson has suffered a legal defeat in its ongoing dispute with consumers over damages relating to use of its baby powder products, after the Missouri Supreme Court rejected the company’s appeal over a payment of $2.12 million to a woman claiming that asbestos in J&J’s talc products led to her developing ovarian cancer.

J&J had disputed a decision by a state appeals court on 23 June that the company was liable to pay damages to plaintiffs, upholding a jury ruling from July 2018 which also dropped the company’s total payout from $4.69 billion after 22 claims we

Roche subsidiary Genentech has revealed that its immunotherapy Tecentriq (atezolizumab), combined with Avastin (bevacizumab), paclitaxel and carboplatin, fell short of its primary endpoint at Phase 3 in the front-line treatment of newly-diagnosed advanced-stage ovarian cancer.

The company admitted that the combo therapy did not meet its main goal of progression-free survival benefit. However, the safety profile of the combo was found to be consistent with previous data.

Lynparza (olaparib), developed by AstraZeneca and MSD, has secured FDA approval when paired with bevacizumab as a first-line maintenance treatment for homologous recombination deficiency (HRD)-positive advanced epithelial ovarian, fallopian tube or primary peritoneal cancer.

The indication covers adult patients who have completely or partially responded to first-line platinum-based chemotherapy and whose HRD-positive status is defined by either a deleterious or suspected deleterious BRCA mutation or genomic instability.

A study by Cancer Research UK has found that women who take statins, drugs that lower cholesterol, are less likely to develop ovarian cancer.

The research was published in JAMA and studied genes and the extent to which they inhibit the enzyme HMG-COA reductase, the enzyme statin targets to reduce cholesterol. The study suggests that statins could lower ovarian cancer risk but highlights that more research needs to be done specifically looking at their use and impact on women’s risk of developing the disease.

Johnson & Johnson have been ordered to pay by a jury $750 million to four plaintiffs over the company’s baby powder product being alleged to contained carcinogens.

The jury concluded that the company had not properly informed consumers of the risk of using the powder. Traces of the carcinogen asbestos can found in talc and can cause mesothelioma.

NICE has given its recommendation for the routine use on the NHS in England and Wales of AstraZeneca and MSD’s Lynparza (olaparib) for the maintenance treatment of relapsed, advanced, BRCA+ ovarian cancer, it has been announced, making the drug available to all BRCA-mutated patients.

Specifically, this new ruling affects adult NHS patients who are living with relapsed, platinum-sensitive high grade epithelial ovarian, fallopian tube or peritoneal cancer with the BRCA1 or BRCA2 mutation (BRCAm) which has responded to platinum-based chemotherapy.

New research from GlobalData has forecast that the worldwide market for ovarian cancer is set to expand at a compound annual growth rate (CAGR) of 14.4% from its 2018 valuation of $1.8 billion to reach $6.7 billion by 2028.

This growth is predicted to be driven predominantly by adoption of maintenance therapy for the disease across the US, UK, France, Germany, Spain, Italy and Japan.

NICE has announced it has made an about-face on its earlier ruling for Clovis Oncology’s Rubraca (rucaparib), revealing that the drug will now be made available immediately via the Cancer Drugs Fund (CDF) for women in England with relapsed ovarian, fallopian tube or peritoneal cancer, that has responded to platinum-based chemotherapy.

The UK watchdog originally turned down the therapy due to concerns over the certainty of the data submitted, as well as over cost-effectiveness, based on the price put forward by Clovis.

At the 2019 European Society for Medical Oncology (ESMO) congress, GlaxoSmithKline unveiled new Phase 3 data on Zejula (niraparib) for the maintenance of first-line ovarian cancer that has responded to platinum-based chemotherapy.

The data revealed that the drug improved progression-free survival (PFS) by 38% in the overall population of the PRIMA study. Within sub-populations of this overall group, the drug was found to improve PFS by 60% in BRCA mutation tumours, 50% in HR-deficient BRCA wild type tumours, and 32% in HR-proficient tumours

New Phase 3 data has emerged on AstraZeneca and MSD’s Lynparza (olaparib), showing that the PARP inhibitor achieved its primary endpoint in the first-line maintenance of advanced ovarian cancer in patients with or without BRCA mutations when added to standard-of-care bevacizumab, compared to bevacizumab alone.

The companies declared that the drug combo was found to produce a £statistically-significant and clinically-meaningful improvement in progression-free survival (PFS)”, marking the second positive set of results for Lynparza in first-line ovarian cancer.