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psoriasis

Lilly's Taltz beats Janssen's Tremfya at Phase 4 in plaque psoriasis

Eli Lilly has unveiled new Phase 4 data supporting the efficacy and safety of Taltz (ixekizumab) when compared to Janssen’s Tremfya (guselkumab), showing that the former met all primary and secondary endpoints in the treatment of moderate to severe plaque psoriasis (PsO).

The 1,027-participant trial is the first to directly compare an IL-17A inhibitor to an IL-23/p19 inhibitor using the Psoriasis Area Severity Index (PASI) 100 score as a primary endpoint to assess their efficacy.

Novartis provides promising update on Cosentyx in plaque psoriasis

Novartis has revealed brief new data on its IL-17A antibody Cosentyx (secukinumab) in the treatment off plaque psoriasis, showing that the therapy “improves inflammation and rapidly supresses IL-23” in cases of the disease.

Published in the Journal of Allergy and Clinical Immunology, the findings indicated that  Cosentyx generated a “substantial improvement” in inflammation for the majority of patients after as little as 12 weeks by modulating gene expression and reversing plaque histopathology.

Bristol-Myers Squibb to sell off Celgene's Otezla ahead of $74 billion merger

Bristol-Myers Squibb has agreed to sell off Celgene’s psoriasis treatment Otezla, to appease antitrust regulators.

BMS will divest one of Celgene’s most lucrative drugs as the two companies prepare for their $74 billion merger. Otezla generated $1.86 billion in sales last year and was previously seen as an important driver of future growth.

However, in light of discussions with the US Federal Trade Commission (FTC), BMS will sell off the psoriasis drug as quickly as possible. BMS expects this date to be in late 2019 or early 2020.

New Phase 3 data confirms safety and efficacy of UCB's Cimzia in plaque and psoriatic arthritis

New Phase 3 data has been released by UCB Pharma on the safety of Cimzia (certolizumab pegol) in the treatment of moderate-to-severe plaque psoriasis, and its efficacy in patients showing signs of psoriasis-related nail disease and those showed an inadequate early treatment response to the drug.

The first 96 weeks of data derived from 995 participants across two ongoing Phase 3 studies demonstrated that “confirmed the long-term safety of Cimzia in the treatment of psoriasis”, with no new safety concerns flagged, while the overall incidence of adverse events was low.

AbbVie's Skyrizi snatches up FDA approval in moderate to severe plaque psoriasis

AbbVie has revealed that its interleukin-23 (IL-23) inhibitor Skyrizi (risankizumab-rzaa) has received marketing authorisation in the US from the FDA in the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

According to the company, Skyrizi produced “high rates of durable skin clearance” in two Phase 3 clinical trials. The approval was based on data which showed that, after 16 weeks, 75% of patients achieved a Psoriasis Area and Severity Index (PASI) score of 90, compared to 5% and 2% of placebo patients.

NICE recommends UCB's Cimzia in severe plaque psoriasis

NICE has announced its decision to recommend UCB Pharma’s Cimzia (certolizumab pegol) for use on the NHS in England in the treatment of severe plaque psoriasis in patients who have failed to respond to, or are unsuitable for, other systemic treatments.

The judgement also adds an additional treatment option for women before or during pregnancy, as well as while breastfeeding.

Novartis' Cosentyx approved in China for plaque psoriasis

Novartis has revealed that its interleukin-17A (IL-17A) Cosentyx (secukinumab) has been authorised for use in China in the treatment of moderate-to-severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy, following review by the country’s National Medical Products Association (NMPA).

The approval was supported by a range of robust data, including from five-year Phase 3 extension studies in psoriasis, psoriatic arthritis and ankylosing spondylitis.

Japan awards AbbVie's Skyrizi with first approval, in 4 psoriasis indications

AbbVie has announced that its interleukin-23 (IL-23) inhibitor Skyrizi (risankizumab) has been awarded approval in Japan from the nation’s Ministry of Health, Labour and Welfare (MHLW), marking its first-ever approval in any region worldwide, in the treatment of plaque psoriasis, generalised pustular psoriasis, erythrodermic psoriasis and psoriatic arthritis in adult patients who have an inadequate response to conventional therapies.

Marketing authorisation was given based on Phase 2 and 3 data evaluating the drug’s efficacy in Japanese patients in the approved indications.

Novartis' Cosentyx tops Janssen's Stelara in moderate-to-severe psoriasis trial

New data has been revealed in support of Novartis’ Cosentyx (secukinumab) in the treatment of moderate-to-severe plaque psoriasis, demonstrating the drug delivered greater quality of life improvements compared to Janssen’s Stelara (ustekinumab) after 16 weeks of treatment.

The data showed that 68.4% of patients receiving Cosentyx experienced no impact of skin disease on their quality of life after 16 weeks of treatment, compared to 55.9% of those receiving Stelara.

AbbVie's Skyrizi scoops up CHMP recommendation for moderate to severe plaque psoriasis

AbbVie’s interleukin-23 (IL-23) inhibitor Skyrizi (risankizumab) has secured recommendation from the EMA’s Committee for Medicinal Products for Human Use (CHMP), it has emerged.

Specifically, the drug has been recommended for the treatment of moderate to severe plaque psoriasis in adults who are eligible for systemic therapy.

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