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Roche's Tecentriq falls short as an adjuvant monotherapy in muscle-invasive urothelial cancer

Roche has released an update on the development of its immunology Tecentriq (atezolizumab), making it known that the drug failed to meet its primary endpoint as a monotherapy after surgery for the treatment of muscle-invasive urothelial cancer (MIUC).

The company confirmed that the therapy did not prove sufficient benefit in improving disease-free survival at Phase 3, falling short of its efficacy goal. The drug’s safety profile, however, was found to be positive and consistent with previous data.

Roche's Tecentriq combo boosts progression-free survival in previously untreated BRAF V600 mutation-positive advanced melanoma

Roche has lifted the curtain on new Phase 3 data for its immunotherapy Tecentriq (atezolizumab), confirming that the therapy, when combined with Cotellic (cobimetinib) and Zelboraf (vemurafenib), met its primary endpoint in the treatment of previously untreated BRAF V600 mutation-positive advanced melanoma.

While specifics of the findings were not revealed, Roche confirmed that the combo generated a “significant and clinically meaningful” improvement in progression-free survival (PFS) compared to placebo plus Cotellic and Zelboraf.

Roche's Tecentriq combo scores FDA approval in non-small cell lung cancer

Roche’s immunotherapy Tecentriq (atelizumab) has chalked up another approval from the FDA, this time in combination with the chemotherapy Abraxane (paclitaxel protein-bound; nab-paclitaxel and carboplatin) for the first-line treatment of metastatic non-squamous non-small cell lung cancer (NSCLC) in adult patients whose tumours display no EGFR or ALK genomic aberrations.

Phase 3 data submitted in support of the approval showed that the combo produced a median overall survival benefit of 18.6 months compared to 13.9 months with chemo alone in the intention-to-treat wild-type populati

Roche's Tecentriq combo outclasses Nexavar in unresectable hepatocellular carcinoma

Roche has revealed new Phase 3 data for its immunotherapy drug Tecentriq (atezolizumab) in combination with Avastin (bevacizumab) in the treatment of unresectable hepatocellular carcinoma (HCC) in patients who have not received prior systemic therapy.

The company announced the findings at the European Society for Medical Oncology (ESMO) Asia Congress 2019 on Saturday.

Roche's Tecentriq/Avastin combo smashes endpoints at Phase 3 in unresectable hepatocellular carcinoma

New Phase 3 data has emerged demonstrating the efficacy of Roche’s Tecentriq (atezolizumab) in combination with Avastin (bevacizumab) in the treatment of unresectable hepatocellular carcinoma (HCC) in patients who have not received prior systemic therapy.

The results, drawn from a trial of 501 unresectable HCC patients, showed that the pair of drugs met the trial’s co-primary endpoints, generating “statistically significant and clinically meaningful improvements” in both overall survival and progression-free survival compared to Nexavar (sorafenib), the current standard of care.

NICE rejects Roche's immunotherapy Tecentriq in unresectable metastatic triple A breast cancer

NICE has revealed its decision not to approve Roche’s immunotherapy Tecentriq (atezolizumab) for use on the NHS in England and Wales for the treatment of unresectable, metastatic triple A breast cancer.

The decision puts the UK watchdog at odds with the FDA and EMA, who both saw fit to approve the drug – their first approved therapy for triple A breast cancer patients. Tecentriq works by blocking PD-L1, and is the first immunotherapy to specifically target tumours which express the protein by 1% or more.

Roche's Tecentriq plus chemo shows promise in first-line, advanced bladder cancer

Roche has revealed data from an interim analysis of its immunotherapy Tecentriq (atezolizumab) at the 2019 European Society for Medical Oncology (ESMO) congress, showing promising performance in combination with platinum-based chemotherapy in the first-line treatment of previously untreated locally advanced or metastatic urothelial carcinoma (mUC) eligible and ineligible for cisplatin chemotherapy.

The Tecentriq combo demonstrated a “statistically significant improvement” in progression-free survival (PFS) of 8.2 months compared to 6.3 months with chemotherapy alone.

Roche celebrates European approval of Tecentriq combo in first-line lung cancer

Roche has confirmed that its immunotherapy Tecentriq (atezolizumab) has been approved in Europe in combination with chemotherapy (carboplatin and etoposide) for the first-line treatment of adults with extensive-stage small cell lung cancer (ES-SCLC).

Phase 3 data submitted in support of the application showed that the Tecentriq combo “helped people live significantly longer compared with chemotherapy alone”, improving median overall survival by 12.3 months compared to 10.3 months with chemotherapy alone in the intent-to-treat population.

Roche's Tecentriq combo becomes first EU-approved immunotherapy for triple-negative breast cancer

Roche has announced the approval of Tecentriq (atezolizumab), in combination with Celgene’s chemotherapy drug Abraxane (nab paclitaxel), by the European Medicines Agency in the treatment of PD-L1-positive, unresectable locally advanced or metastatic triple-negative breast cancer, making it the first immunotherapy regimen available in the continent for this indication.

Roche's Tecentriq meets primary endpoint in Phase 3 bladder cancer trial

Roche has said its immunotherapy drug Tecentriq (Atezolizumab), when used in combination with platinum-based chemotherapy, significantly reduced the risk of disease worsening and death in a Phase 3 trial of patients with bladder cancer.

Roche’s immunotherapy, in combination with chemotherapy, met its primary endpoint in the IMvigor130 Phase 3 trial after significantly reducing the chance of disease worsening or death in people with previously untreated, locally advanced or metastatic urothelial carcinoma (mUC) compared with chemotherapy alone.

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