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BMS' Opdivo+Yervoy combo fails in small cell lung cancer

Published on 27/11/18 at 11:17am

Bristol-Myers Squibb has revealed that its combo comprising Opdivo (nivolumab) and Yervoy (ipilimumab) failed to meet its primary endpoint as a maintenance treatment for extensive-stage small cell lung cancer (SCLC) without disease progression following the completion of first-line platinum-based chemotherapy.

Compared to placebo, the manufacturer said that its PD-1 inhibitor/CTLA-4 inhibitor combo failed to improve the Phase 3 trial’s primary endpoint of overall survival compared to placebo. It is not known whether the therapy managed to meet its secondary endpoint of overall survival improvement for Opdivo as a monotherapy.

News of the failure send shares falling by 4%. BMS said that it would be working with investigators on the study to ensure the publication of full results from the study.

Matt Fellows

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