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Lilly’s LOXO-292 shrinks tumours in lung cancer trial

Published on 09/09/19 at 12:57pm

Eli Lilly has announced its experimental cancer drug LOXO-292, acquired in January, shrank tumours in almost 70% of advanced lung cancer  patients.

LOXO-292 (selpercatinib) treatment resulted in a 68% objective response in patients who had been previously heavily pre-treated with at least 48% of those having received at least one multikinase inhibitor. Additionally in 11 patients whose cancer had spread to the brain, 91% saw tumour shrinkage by 30% or more.

LOXO-292 is intended for patients with rare RET abnormalities occurring in 2% of non-small cell lung cancers (NSCLC) patients as well as 10-20% of papillary thyroid cancers and around 60% of medullary thyroid cancers.

Dr Alexander Drilon, lead investigator at the Memorial Sloan Kettering Cancer Center in New York, said: “We are encouraged by these data as there is currently an unmet need to provide genomically-tailored therapy to patients with RET fusion-positive NSCLCs.

“We look forward to submitting the NDA later this year, and should selpercatinib receive regulatory approval, patients with RET fusion-positive NSCLC will finally have their first genomically guided medicine.”

Safety analyses showed that, out of 531 patients, only nine dropped out due to side-effects. The most commonly reported side-effects were diarrhoea, dry mouth, increased liver enzymes, fatigue, high-blood pressure and headache.

Other investigations into highly selective RET inhibitors include RXDX-105 and BLU-667, the latter of which is set to be filed for FDA approval by its owner Blueprint Medicines in the first quarter of 2020.

Nikhil Kiran

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