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Pfizer reveals strong Phase 3 data for abrocitinib in atopic dermatitis

Published on 14/10/19 at 11:14am

Pfizer confirmed over the weekend that its oral Janus kinase 1 (JAK1) inhibitor abrocitinib met all of its co-primary and key secondary endpoints in a 12-week, Phase 3 study investigating its efficacy in the treatment of moderate to severe atopic dermatitis (AD) in patients aged 12 and older.

The findings revealed that 43.8% and 23.7% of patients achieved an Investigator Global Assessment (IGA) score of clear (0) or almost clear (1) skin with 200mg and 100mg of abrocitinib respectively compared to placebo – one of the trial’s co-primary endpoints. For the other endpoint, 62.7% and 39.7% taking 200mg and 100mg of abrocitinib respectively achieved at least a 75% or greater change from baseline in their Eczema Area and Severity Index (EASI) score, compared to 11.8% with placebo.

Furthermore, 38.6% and 18.6% of 200mg and 100mg abrocitinib patients respectively achieved an EASI score of at least 90 compared to 5.3% for placebo, meeting a key secondary endpoint of the study.

The results were presented at the 28th Congress of the European Academy of Dermatology and Venereology (EADV) in Madrid.

“There is a critical need for additional treatment options for patients living with moderate to severe atopic dermatitis,” said Dr Michael Corbo, Chief Development Officer, Inflammation & Immunology, at Pfizer Global Product Development. “We are pleased by these findings, which together with the recently reported positive top-line results from our second Phase 3 trial, encourage us that, if approved, abrocitinib may provide the first oral, once-daily treatment option for these patients.”

Matt Fellows

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