Skip to NavigationSkip to content

Eli Lilly's diabetes drug tirzepatide reduces blood glucose and weight in Phase III trials

Published on 18/02/21 at 09:21am

Eli Lilly’s tirzepatide led to significant haemoglobin A1C (HbA1C) and body weight reductions from baseline in adults with type 2 diabetes in the SURPASS-3 and SURPASS-5 Phase III clinical trials, after 52 weeks and 40 weeks, respectively.

Tirzepatide is a novel investigational once-weekly, dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist that integrates the actions of both incretins into a single molecule, representing a new class of medicines being studied for the treatment of type 2 diabetes.

In top-line results, the primary and all key secondary endpoints were met for both efficacy and treatment-regimen estimands in SURPASS-3, which compared tirzepatide with titrated insulin degludec, and in SURPASS-5, which compared tirzepatide with a placebo, both as an add-on to titrated insulin glargine.

The highest dose of tirzepatide reduced HbA1C by 2.37% and body weight by 12.9kg in SURPASS-3, and reduced HbA1C by 2.59% and body weight by 10.9kg in SURPASS-5. At the highest dose, 62.4% of SURPASS-5 participants – who had a mean duration of diabetes of 13.3 years – achieved an HbA1C of less than 5.7%, the level seen in people without diabetes.

In both studies, the overall safety profile of the drug similar to that of the well-established GLP-1 receptor agonist class, with gastrointestinal side effects being the most commonly reported adverse events and decreasing with continued dosing.

Mike Mason, President of Lilly Diabetes, said: “Tirzepatide delivered impressive HbA1C and body weight reductions in both studies and continued to achieve consistent efficacy and safety results in people living with type 2 diabetes, regardless of how long they have had the condition.

“Significantly lowering HbA1C levels and weight are high priorities throughout the type 2 diabetes treatment journey, and the results we have seen from three SURPASS studies to date fuel our belief in tirzepatide’s ability to meet those needs.”

Darcy Jimenez

Mission Statement
Pharmafile.com is a leading portal for the pharmaceutical industry, providing industry professionals with pharma news, pharma events, pharma service company listings and pharma jobs,
Site content is produced by our editorial team exclusively for Pharmafile.com and our industry newspaper Pharmafocus. Service company profiles and listings are taken from our pharmaceutical industry directory, Pharmafile, and presented in a unique Find and Compare format to ensure the most relevant matches