Skip to NavigationSkip to content

NICE turns down Astellas' Xtandi in prostate cancer

Published on 08/04/19 at 12:44pm

Astellas’ Xtandi (enzalutamide) has been rejected by UK medicines watchdog NICE for use on the NHS as a therapy for prostate cancer, it has emerged, meaning patients may need to wait until a later stage of their disease in order to access the drug on the health service.  

Xtandi was assessed in a study of 1,401 participants, with 933 patients with non-metastatic prostate cancer taking Astellas’ testosterone-blocking drug, with the rest taking placebo. It was found that the therapy improved progression-free survival by 36.6 months on average versus 14.7 months with placebo.

Despite these promising findings, NICE judged that these data are not mature enough to prove the drug’s efficacy conclusively, arguing that the trial has not run for long enough to adequately show its ability to boost survival rates. Because of this lack of data, NICE could not consider the treatment a cost-effective use of NHS resources, and noted that earlier use of the drug could limit future options for patients.

“This decision may be disappointing for people affected by prostate cancer. Clinical trial evidence suggested this drug could give patients more time before the disease begins spreading to other parts of the body,” commented Emlyn Samuel, Head of Policy Development at Cancer Research UK. “NICE have concluded on the basis of the available evidence that the drug may offer patients greater benefit in the long-run if it is saved for use at a later stage of the disease – where it is already approved for NHS patients.”

Matt Fellows


Thanks for a wonderful share. Your article has proved your hard work and experience you have got in this field. Brilliant .i love it reading. order kratom

Great survey, I'm sure you're getting a great response. Hammock Swing

Great post, and great website. Thanks for the information! Therapist Newport Beach

I think this is an informative post and it is very useful and knowledgeable. therefore, I would like to thank you for the efforts you have made in writing this article. average cost to tear off and replace roof

Nice Informative Blog having nice sharing.. Chicago and Suburbs wedding Photography

Thanks for the post and great tips..even I also think that hard work is the most important aspect of getting success.. doggie birthday cake

I read that Post and got it fine and informative. Please share more like that... iPhone screen repair fort wayne

These are some great tools that i definitely use for SEO work. This is a great list to use in the future.. Boise cabinet refacing

Thanks for sharing nice information with us. i like your post and all you share with us is uptodate and quite informative, i would like to bookmark the page so i can come here again to read you, as you have done a wonderful job. gm1 ganglioside

Please share more like that. brick repointing

Thanks for the valuable information and insights you have so provided here... doglovers

Great info! I recently came across your blog and have been reading along. I thought I would leave my first comment. I don’t know what to say except that I have. RH

This was really an interesting topic and I kinda agree with what you have mentioned here! Fire cupping

I have read your article, it is very informative and helpful for me.I admire the valuable information you offer in your articles. Thanks for posting it.. self-defense school in Maryland

I read a article under the same title some time ago, but this articles quality is much, much better. How you do this.. manager en interne la mobilité internationale

The post is written in very a good manner and it contains many useful information for me. outcall massage

I just found this blog and have high hopes for it to continue. Keep up the great work, its hard to find good ones. I have added to my favorites. Thank You. tattoos and piercings in fayetteville nc

Really a great addition. I have read this marvelous post. Thanks for sharing information about it. I really like that. Thanks so lot for your convene. sell unused diabetic test strips

Superbly written article, if only all bloggers offered the same content as you, the internet would be a far better place.. australian swimwear

this is really nice to read..informative post is very good to read..thanks a lot! emergency locksmith

Positive site, where did u come up with the information on this posting? I'm pleased I discovered it though, ill be checking back soon to find out what additional posts you include. Counseling for young adults near me

Great things you’ve always shared with us. Just keep writing this kind of posts.The time which was wasted in traveling for tuition now it can be used for studies.Thanks homes in new jersey

I would like to thank you for the efforts you have made in writing this article. I am hoping the same best work from you in the future as well.. boston consulting group

I learn some new stuff from it too, thanks for sharing your information. where can i get a notary

I really loved reading your blog. It was very well authored and easy to understand. Unlike other blogs I have read which are really not that good.Thanks alot! wedding photographer

You’ve got some interesting points in this article. I would have never considered any of these if I didn’t come across this. Thanks! Gamerz Planets

I found your this post while searching for information about blog-related research ... It's a good post .. keep posting and updating information. teaching English to Asian students

The post is written in very a good manner and it contains many useful information for me. long distance movers

Excellent information on your blog, thank you for taking the time to share with us. Amazing insight you have on this, it's nice to find a website that details so much information about different artists. security company in Nottingham

Thank you for taking the time to publish this information very useful! Holm Law Group San Diego

I was reading your article and wondered if you had considered creating an ebook on this subject. Your writing would sell it fast. You have a lot of writing talent. a level physics tuition

Wow, this is really interesting reading. I am glad I found this and got to read it. Great job on this content. I like it. website builder diy

Nice post mate, keep up the great work, just shared this with my friendz stardew valley wie komme ich ins casino

Its a great pleasure reading your post.Its full of information I am looking for and I love to post a comment that "The content of your post is awesome" Great work. is the best in free stuff

I really appreciate this wonderful post that you have provided for us. I assure this would be beneficial for most of the people. Poker Online

I was looking at some of your posts on this website and I conceive this web site is really instructive! Keep putting up..

This particular papers fabulous, and My spouse and i enjoy each of the perform that you have placed into this. I’m sure that you will be making a really useful place. I has been additionally pleased. Good perform!

Very useful info. Hope to see more posts soon!. Situs Slot

This is such a great resource that you are providing and you give it away for free. Don Wharton job

I high appreciate this post. It’s hard to find the good from the bad sometimes, but I think you’ve nailed it! would you mind updating your blog with more information? goldco precious metals

I just couldn't leave your website before telling you that I truly enjoyed the top quality info you present to your visitors? Will be back again frequently to check up on new posts. oncologist hospitals in Hyderabad

You know your projects stand out of the herd. There is something special about them. It seems to me all of them are really brilliant! amazing lover

I know your expertise on this. I must say we should have an online discussion on this. Writing only comments will close the discussion straight away! And will restrict the benefits from this information. us money reserve wings of gratitude

I haven’t any word to appreciate this post.....Really i am impressed from this post....the person who create this post it was a great human..thanks for shared this with us. roofing prices

This was a really great contest and hopefully I can attend the next one. It was alot of fun and I really enjoyed myself.. Off leash training Houston

Great article with excellent idea!Thank you for such a valuable article. I really appreciate for this great information.. Candle

Thanks for every other informative site. The place else may just I get that kind of information written in such an ideal means? I have a venture that I’m just now operating on, and I have been on the look out for such information. Golden Retriever Dog Training Houston TX

Wow, cool post. I’d like to write like this too – taking time and real hard work to make a great article… but I put things off too much and never seem to get started. Thanks though. Mark Hauser

Thanks for a wonderful share. Your article has proved your hard work and experience you have got in this field. Brilliant .i love it reading. nabeer

I found this is an informative and interesting post so i think so it is very useful and knowledgeable. I would like to thank you for the efforts you have made in writing this article. คาสิโนออนไลน์

Mission Statement is a leading portal for the pharmaceutical industry, providing industry professionals with pharma news, pharma events, pharma service company listings and pharma jobs,
Site content is produced by our editorial team exclusively for and our industry newspaper Pharmafocus. Service company profiles and listings are taken from our pharmaceutical industry directory, Pharmafile, and presented in a unique Find and Compare format to ensure the most relevant matches