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AZ's Tagrisso extends median overall survival by over 3 years in metastatic, EGFR-mutated lung cancer

Published on 30/09/19 at 10:16am

AstraZeneca took to the stage at the 2019 European Society for Medical Oncology (ESMO) Congress in Barcelona to present new data on Tagrisso (osimertinib) in the first-line treatment of locally-advanced or metastatic epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC).

Tagrisso was shown to present a “statistically significant and clinically meaningful improvement” in overall survival, extending life by a median of 38.6 months compared to 31.8 months with previous standards of care gefitinib and erlotinib.

After three years of treatment, 28% of Tagrisso patients remained on the first-line study treatment versus just 9% in the study’s comparator arm. Additionally, Tagrisso was shown to reduce the risk of central nervous system disease progression by 52% and extend the length of time patients with CNS metastases lived without CNS disease progression or death.

According to AZ, the drug is the only first-line therapy “to deliver a median overall survival of more than three years” in this indication.

 “Tagrisso has set a new benchmark in EGFR-mutated non-small cell lung cancer by demonstrating a median overall survival of more than three years,” commented José Baselga, Executive Vice President, Oncology R&D.  “We have not before seen survival benefits of this magnitude in any global Phase 3 trial with any such therapy. The ground-breaking data reaffirm the benefit of using Tagrisso first and further support its use as the 1st-line standard of care in this setting.”

Matt Fellows

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