Lynparza tablets approved for NHS use in platinum-sensitive, BRCA-mutated ovarian, fallopian tube or peritoneal cancer
pharmafile | January 16, 2020 | News story | Sales and Marketing | AstraZeneca, MSD, NHS, NICE, UK, lynparza
It has been announced that tablet form of Lynparza (olaparib), the PARP inhibitor developed by AstraZeneca and MSD, has secured recommendation from NICE for the treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer in adult patients with a BRCA1 or BRCA2 mutation.
Data supplied in support of the case for the drug’s recommendation demonstrated that Lynparza presented a progression-free survival benefit of 19.1 months, compared to 5.5 months for placebo.
The decision means that Lynparza tablets will now be made available to NHS patients in England and Wales who have previously undergone at least three courses of platinum-based chemotherapy.
While the therapy meets NICE’s end-of-life criteria and was deemed cost-effective in this group, it does not in patients who have only received two courses. As a result, NICE believes it has the potential to be cost-effective and has asked for further confirmatory data on overall survival benefit.
In the meantime, it has recommended that the drug be made available via the Cancer Drugs Fund in this patient population, which is estimated to be around 1,100.
NICE previously recommended Lynparza in capsule formulation for patients with a BRCA mutation who have previously received at least three courses of platinum-based chemo.
Matt Fellows
Related Content
NICE recommends migraine treatment for NHS use
The National Institute for Health and Care Excellence (NICE) has shared draft guidance recommending AbbVie’s …
AstraZeneca shares results for Imfinzi in phase 3 trial for small cell lung cancer
AstraZeneca has announced positive high-level results from the phase 3 ADRIATIC trial, which demonstrated that …
FDA accepts BLA for AstraZeneca and Daiichi Sankyo’s datopotamab deruxtecan for breast cancer treatment
AstraZeneca and Daiichi Sankyo have announced that their Biologics License Application (BLA) for datopotamab deruxtecan …